RNA activation (RNAa) is a small RNA-guided and (Ago)-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional/epigenetic level. RNAa was first reported in a 2006 PNAS paper by Li et al. Who also coined the term 'RNAa' as a contrast to () to describe such gene activation phenomenon. Soon after, several groups made similar observation in different mammalian species including human, non-human primates, rat and mice, suggesting that RNAa is a general gene regulation mechanism conserved at least in mammals. In these studies, upregulation of gene expression is achieved by targeting selected promoter regions using either synthetic 21-nucleotide dsRNAs or vector expressed small hairpin RNAs (shRNAs). Such promoter targeted dsRNAs have been termed antigene RNA (agRNAs) or (). Similar gene activation mechanisms mediated by the Ago-small RNA pathway have also been observed in plants and C. Contents • • • • • • Mechanism of RNAa [ ] The molecular mechanism of RNAa is not fully understood. Similar to RNAi, it has been shown that mammalian RNAa requires members of the Ago clade of proteins, particularly Ago2, but possesses kinetics distinct from RNAi. In contrast to RNAi, promoter-targeted agRNAs induce prolonged activation of gene expression associated with epigenetic changes. It is currently suggested that saRNAs are first loaded and processed by an Ago protein to form an Ago-RNA complex which is then guided by the RNA to its promoter target. The target can be a non-coding transcript overlapping the promoter or the chromosomal DNA. The RNA-loaded Ago then recruits other proteins such as, also known as nuclear DNA helicase II, and to form an RNA-induced transcriptional activation (RITA) complex. RITA can directly interacts with to stimulate and productive transcription elongation which is related to increased of H2B. Endogenous RNAa [ ] In 2008, Place et al. Identified targets for miR-373 on the promoters of several human genes and found that introduction of miR-373 mimics into human cells induced the expression of its predicted target genes. This study provided the first example that RNAa could be mediated by naturally occurring (). In 2011, Huang et al. Further demonstrated in mouse cells that endogenous RNAa mediated by miRNAs functions in a physiological context and is possibly exploited by cancer cells to gain a growth advantage. Since then, a number of miRNAs have been shown to upregulate gene expression by targeting gene promoters or enhancers. A good example is miR-551b-3p which is overexpressed in ovarian cancer due to amplification. MiR-551b-3p confers to ovarian cancer cells resistance to apoptosis and a proliferative advantage by targeting the promoter of to increase its transcription. Elegans, Argonaute CSR-1 interacts with 22G small RNAs derived from and antisense to germline-expressed transcripts to protect these mRNAs from - mediated silencing via promoting epigenetic activation. Elegans hypodermal seam cells, the transcription of miRNA is positively regulated by lin-4 itself which binds to a conserved lin-4 complementary element in its promoter, constituting a positive autoregulatory loop. Applications of RNAa [ ] RNAa has been used to study gene function in lieu of vector-based gene overexpression. Studies have demonstrated RNAa in vivo and its potential therapeutic applications in treating cancer and non-cancerous diseases. In June 2016, UK-based MiNA Therapeutics announced the initiation of a phase I trial of the first-ever saRNA drug MTL-CEBPA in patients with liver cancer, in an attempt to activate gene. References [ ]. Two nights ago, before I went to sleep, I asked the Creation to guide me to another important subject. The next morning, my father called me to say that scientists made strange discoveries regarding the human DNA. Even though I usually 'administrate' this kind of information to my father 'by force', now he was the one updating me. Even so, I haven't payed attention to this subject until later that evening. To be honest, I was amazed to read that the modern medicine finally released to the press that the 'first human with 3 DNA strands' has been born. Of course, the case of little Alfie is the first one to be officially acknowledge by the medical community, but not the only one existent. In fact, I've read years ago that independent doctors were already working with children who developed the third DNA strand. But are they different than the average human? I am absolutely delighted to inform you that they are very special and in fact all humans are mutating to a superior species, as we speak. According to dna-activation-power.com, people who have undergone 12 strand DNA activation are supposed to be telepathic, be able to heal others and reverse the aging process e.t.c I'd love to see that DNA under the microscope - maybe I can convince the owner of the website to send me a sample. DNA Activation (also known as 'Life Activation') is an ancient empowerment process that 'lights up' your DNA at a spiritual level. That may be the. BUY THREE 12-STRAND DNA ACTIVATIONS AND WE'LL THROW IN TEN STRANDS FOR FREEEEEE! Please relax and enjoy the article! The modern medicine officially acknowledged the first case of a child with 3 DNA strands - Finally! A microscopic image of human chromosomes. Little Alfie Clamp has an 'extra arm' on one of his, in what is believed to be a world first. His condition left Alfie unable to see until he was three months old and his muscles were so weak he could not roll over on his own. He still suffers serious digestive problems and needs a cocktail of drugs every day to help his body absorb vital nutrients. He also suffers fits which sparked by high temperatures and metabolic problems stop him from eating or drinking. Since he was born, Alfie has been rushed to hospital six times - including twice just last month - when he stopped breathing. His parents even believed he was dying twice and were stunned when Alfie made a full recovery after spending time in hospital. Mr and Mrs Clamp, who also have 10-year-old daughter Georgia who is perfectly healthy, had their DNA tested but were not carriers of the faulty gene. Mr Clamp said: 'The doctors told us there is nothing we could have done to prevent it. I don't think we'll ever know why it happened. 'I was holding him in my arms and I could see his eyes start to focus on me. It was a massive milestone for us because we didn't know if that would ever happen. 'We even took a photograph of the two of us sat there, looking at each other. Having Alfie has changed our lives - everything revolves around him. But he is such a happy boy and he has brought a lot of joy to our lives. 'Whenever we go to hospital, all the doctors and nurses say what a pleasure it is to see Alfie.' It is speculated that the human beings already had 12 DNA strands hundreds of thousands of years ago, but someone or something interfered in our evolution, downgrading us to only two. It is not just we humans who are changing, but all life forms on Earth are becoming crystalline. All the fish in the sea, the flowers and trees in your garden, the birds in the sky, even your pet dog or cat. Everything is changing. Nothing will die or be destroyed, for we are all moving together into A NEW STATE OF BEING. This new state of being requires therefore that we physically, mentally and emotionally let go of 3rd dimensional concepts. To relieve muscle spasm take Valerian and try mud baths or a long, hot soak in a bath to which you add a cup of Epsom salts. Do this daily. Rocognise that even if you are having heart palpitations or breathing difficulties that it is the heart chakra or the throat chakra.that is unblocking and that the symptoms are temporary. You aren't dying, just changing! However, don't just take my word for it. Seek medical guidance if you are unsure. If you don't know where to get Valerian or Fenugreek, try a health food store or better still, simply say the name in your head when you need relief. All healing energies are transmitted via the sound of the name and are just as effective said in the mind or aloud, as in physically taking them. Try it and see. Ask your angel guides to help relieve any pain. They are just waiting to be asked! Most symptoms seem to last a couple of weeks, then clear up. Some symptoms may recur from time to time. These changes are not necessarily being experienced by everyone concurrently. A very small percentage of adults have already completed the entire change into crystalline form and now embody 1,024 strands of DNA. Deoxyribonucleic acid (DNA) is a nucleic acid that contains all the genetic instructions used in the development and functioning of all known living things. The main role of DNA is the long-term storage of information. DNA is often compared to a set of blueprints since it contains the instructions needed to construct other components of cells.The DNA segments that carry genetic information are called genes, but other DNA sequences have structural purposes or are involved in regulating the use of genetic information. The original Human Being had 12 Strands of DNA actively working and maintaining the full function of the Human as a Spiritual Being. With our over preoccupation with left brained thinking and the closing down of our heart centers, these ‘extra’ DNA strands have been lost. The consequences of this loss are that we live in a spiritually deficient society and our intuitive and healing abilities have been hugely reduced. It has also resulted in us only accessing and using a very small part of our brains.
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